Antihistamine use in children

R Fitzsimons, LA van der Poel, W Thornhill… - Archives of Disease in …, 2015 - ep.bmj.com
This review provides an overview of the use of antihistamines in children. We discuss types
of histamine receptors and their mechanism of action, absorption, onset and duration of …

G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain

A Ponce, E Bueno, C Kentros… - Journal of …, 1996 - Soc Neuroscience
G-protein-gated inward rectifier potassium (GIRK) channels are coupled to numerous
neurotransmitter receptors in the brain and can play important roles in modulating neuronal …

[HTML][HTML] Glycosylation affects the protein stability and cell surface expression of Kv1. 4 but not Kv1. 1 potassium channels: a pore region determinant dictates the effect …

I Watanabe, J Zhu, E Recio-Pinto… - Journal of Biological …, 2004 - ASBMB
Kv1. 1 and Kv1. 4 potassium channels are plasma membrane glycoproteins involved in
action potential repolarization. We have shown previously that glycosylation affects the …

Neuraminidase treatment modifies the function of electroplax sodium channels in planar lipid bilayers

E Recio-Pinto, WB Thornhill, DS Duch, SR Levinson… - Neuron, 1990 - cell.com
Sodium channels from several sources are covalently modified by unusually large numbers
of negatively charged sialic acid residues. In the present studies, purified electroplax sodium …

Glycosylation affects rat Kv1. 1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism

I Watanabe, HG Wang, JJ Sutachan… - The Journal of …, 2003 - Wiley Online Library
The effect of glycosylation on Kv1. 1 potassium channel function was investigated in
mammalian cells stably transfected with Kv1. 1 or Kv1. 1N207Q. Macroscopic current …

The glycosylation state of Kv1. 2 potassium channels affects trafficking, gating, and simulated action potentials

I Watanabe, J Zhu, JJ Sutachan, A Gottschalk… - Brain research, 2007 - Elsevier
We presented evidence previously that decreasing the glycosylation state of the Kv1. 1
potassium channel modified its gating by a combined surface potential and a cooperative …

The Kv1. 3 potassium channel is localized to the cis‐Golgi and Kv1. 6 is localized to the endoplasmic reticulum in rat astrocytes

J Zhu, J Yan, WB Thornhill - The FEBS journal, 2014 - Wiley Online Library
The functions of voltage‐gated potassium (Kv) channels in neurons have been well defined,
whereas their roles in glial cells are not fully understood. Kv1. 1, Kv1. 3 and Kv1. 6 are …

[HTML][HTML] Expression of Kv1. 1 delayed rectifier potassium channels in Lec mutant Chinese hamster ovary cell lines reveals a role for sialidation in channel function

WB Thornhill, MB Wu, X Jiang, X Wu, PT Morgan… - Journal of Biological …, 1996 - ASBMB
Kv1. 1 potassium (K+) channels contain significant amounts of negatively charged sialic
acids. To examine the role of sialidation in K+ channel function, Chinese hamster ovary cell …

[HTML][HTML] Determinants involved in Kv1 potassium channel folding in the endoplasmic reticulum, glycosylation in the Golgi, and cell surface expression

J Zhu, I Watanabe, B Gomez, WB Thornhill - Journal of Biological Chemistry, 2001 - ASBMB
Kv1. 1 and Kv1. 4 potassium channels are expressed as mature glycosylated proteins in
brain, whereas they exhibited striking differences in degree of trans-Golgi glycosylation …

[HTML][HTML] Phosphorylation of a K+ channel α subunit modulates the inactivation conferred by a β subunit: Involvement of cytoskeleton

G Levin, D Chikvashvili, D Singer-Lahat… - Journal of Biological …, 1996 - ASBMB
Voltage-gated K+ channels isolated from mammalian brain are composed of α and β
subunits. Interaction between coexpressed K v 1.1 (α) and K v β1. 1 (β) subunits confers …