Pharmacokinetics of levetiracetam in neonates with seizures

J Pediatr. 2011 Jul;159(1):152-154.e3. doi: 10.1016/j.jpeds.2011.03.057. Epub 2011 May 18.

Abstract

The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anticonvulsants / pharmacokinetics*
  • Anticonvulsants / therapeutic use
  • Body Weight
  • Chromatography, Liquid
  • Creatinine / blood
  • Female
  • Half-Life
  • Humans
  • Infant, Newborn
  • Intensive Care Units, Neonatal
  • Levetiracetam
  • Male
  • Multivariate Analysis
  • Piracetam / analogs & derivatives*
  • Piracetam / pharmacokinetics
  • Piracetam / therapeutic use
  • Prospective Studies
  • Seizures / drug therapy*
  • Tandem Mass Spectrometry

Substances

  • Anticonvulsants
  • Levetiracetam
  • Creatinine
  • Piracetam