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Detection of Helicobacter pylori Organisms by Hp-Fast in Children

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Abstract

Hp-fast is a new rapid urease test (RUT) thathas not been evaluated in children. The aim of the studywas to prospectively compare the Hp-fast test to theCLOtest in children. Children with gastrointestinal symptoms who undergo diagnostic upper endoscopywere prospectively enrolled to the study. Antral gastricbiopsies were evaluated for histology and for CLO-testand Hp-fast. Results were then compared to histology. Of the 94 children who participated,gastritis was found in 38 (40%), of whom 16 (42%) hadassociated H. pylori organisms. In two children, H.pylori organisms were identified without gastritis. The concordance between both RUT tests was 98%.A significant correlation was found between RUT resultsand histological factors or serology. The accuracy rateof both RUT increased significantly when different gold standards were utilized todetect Hp infection in children. The best correlationwas found when histology and serology were considered asthe gold standard for the diagnosis of H. pylori infection in children (sensitivity: 100%compared to 43-80% with other standards, respectively).In conclusion, the Hp-fast test result is comparable toCLOtest, but neither alone is sufficient to establish the diagnosis of Hp infection inchildren.

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REFERENCES

  1. Cohen H, Bautista L, Crowe H, Johnson C, Rose LS, Pronovost AD: Comparison of culture and histology to seven commercial tests for Helicobacter pylori. Am J Gastroente rol 90:1579, 1995 (abstract)

    Google Scholar 

  2. Laine L, Lewin DN, Naritoku W, Estrada R, Cohen H: Prospective comparison of commercially available rapid urease tests for the diagnosis of H. pylori. Gastrointest Endosc 45:463–467, 1997

    Google Scholar 

  3. Chong SKF, Lou Q, Asnicar MA, et al: Helicobacter pylori infection in recurrent abdominal pain in childhood: Comparison of diagnostic tests and therapy. Pediatrics 96:211–215, 1995

    Google Scholar 

  4. Yousfi MM, El-Zimaity HMT, Cole RA, Genta RM, Graham DY: Detection of Helicobacter pylori by rapid urease tests: Is biopsy size a critical variable? Gastrointest Endosc 43:222–224, 1996

    Google Scholar 

  5. Elitsur Y, Neace C, Triest WE: Comparison between a rapid office-based and ELISA serologic test in screening for H. pylori in children. Helicobacter 2:180–184, 1997

    Google Scholar 

  6. Elitsur Y, Hill I, Lichtman SN, Rosenberg AJ: Prospective comparison of rapid urease tests (Pyloritek, CLOte st) for the diagnosis of H. pylori infection in symptomatic children: A pediatric multicenter study. Am J Gastroenterol 93:217–219, 1998

    Google Scholar 

  7. Sue SY, Sheu BS, Yang SB, Chen CY, Lin XZ: One-minute ultrarapid urease test for detection of H. pylori: a comparison to other rapid urease tests. Gastroenterology 112:A299, 1997 (abstract)

    Google Scholar 

  8. Laine L, Chun D, Stein C, El-Beblawi I, Sharma V, Chandrasoma P: The influence of size or number of biopsies on rapid urease test results: A prospective evaluation. Gastrointest Endosc 43:49–53, 1996

    Google Scholar 

  9. Lee JG, Lam K, Solnick J, Leung JW, Hsu R: The effects of storage temperature, incubation conditions, and contaminants on the sensitivity of CLO, Hp-fast, and Pyloritek for the detection of H. pylori. Gastrointest Endosc 45:AB95, 1997 (abstract)

    Google Scholar 

  10. Gottrand F, Cullu F, Turck D, Vincent P, Michaud L, Husson MO, e t al: Normal gastric histology in Helicobacter pylori-infected children. J Pe diatr Gastroenterol Nutr 25:74–78, 1997

    Google Scholar 

  11. Elitsur Y: H. pylori infection and gastritis. J Pediatr Gastroenterol Nutri 26:365–366, 1998 (letter)

    Google Scholar 

  12. Kalach N, Briet F, Raymond J, Benhamou P-H, Barbet P, Bergeret M, Senouci L, Maurel M, Flourie B, Dupont C: The 13carbon urea bre ath test for the noninvasive detection of Helicobacter pylori in children: Comparison with culture and dete rmination of minimum analysis requirements. J Pediatr Gastroenterol Nutr 26:291–296, 1998

    Google Scholar 

  13. Bode G, Rothenbacher D, Brenner H, Adler G: Variation in 13C-urea breath test value by nationality in Helicobacter pyloriinfected children. Scand J Gastroenterol 33:468–472, 1998

    Google Scholar 

  14. Elitsur Y, Neace C, Aflak R, Triest WB: Is H. pylori serology a reliable screening method for HP-gastritis in children? Gastrointest Endosc 45:AB90, 1997 (abstract)

    Google Scholar 

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Authors
  1. Yoram Elitsur
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  2. Cheryl Neace
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Elitsur, Y., Neace, C. Detection of Helicobacter pylori Organisms by Hp-Fast in Children. Dig Dis Sci 44, 1169–1172 (1999). https://doi.org/10.1023/A:1026680324734

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