Drug screening of meconium in infants of drug-dependent mothers: An alternative to urine testing
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Drug testing in support of the diagnosis of neonatal abstinence syndrome: The current situation
2023, Clinical BiochemistryCitation Excerpt :The proposed mechanism is that the fetus, once exposed to drug via passive diffusion across the placenta [47], excretes drug into bile and amniotic fluid. Drug accumulates in meconium either by direct deposition from bile or through swallowing of amniotic fluid [14,39,48]. The first evidence of meconium in the foetal intestine appears at approximately the 10th week to 12th week of gestation, and slowly moves into the colon by the 16th week of gestation [38] The presence of drugs in meconium has been proposed to be indicative of in utero drug exposure occurring from the end of the second trimester through the third trimester [39,49,50].
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2020, Microchemical JournalCitation Excerpt :It begins to form in fetus gastrointestinal tract between 12 and 16 weeks of pregnancy and accumulates until birth [24]. Meconium, unlike later feces has usually very dark green color and it is almost odorless [25]. It has a complex matrix composed of amniotic fluid residue, cellular debris like flaked cells of the skin and of digestive tract, gastrointestinal secretions and enzymes, lanugo, fatty material from the vernix caseosa, cholesterol and precursors of sterols, bile acids and salts, mucopolysaccharide blood group substances [26], proteins [27], sugars [28] as well as trace elements [29].
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