Elsevier

Pediatric Neurology

Volume 2, Issue 6, November–December 1986, Pages 321-328
Pediatric Neurology

Review article
Megalencephaly: Types, clinical syndromes, and management

https://doi.org/10.1016/0887-8994(86)90072-XGet rights and content

Abstract

The differential diagnosis of megalencephaly poses a challenge to the clinician. The two major categories, metabolic and anatomic, include a number of conditions, many of them rare. This article provides a systematic approach to the patient with megalencephaly.

References (48)

  • M Dambska et al.

    An autopsy case of hemimegalencephaly

    Brain Dev

    (1984)
  • AS Fremion et al.

    Apnea as the sole manifestation of cord compression in achondroplasia

    J Pediatr

    (1984)
  • DD Weaver et al.

    Familial variation of head size and adjustment for parental head circumference

    J Pediatr

    (1980)
  • G. van Walsem

    Ueber das Gewicht des schwersten bis jetzt beschriebenen Gehirns

    Neurol Centralbl

    (1899)
  • J Lorber et al.

    Children with large heads: A practical approach to diagnosis in 557 children, with special reference to 109 children with megalencephaly

    Dev Med Child Neurol

    (1981)
  • KM Laurence

    Megalencephaly

    Dev Med Child Neurol

    (1964)
  • W DeMyer

    Megalencephaly in children. Clinical syndromes, genetic patterns, and differential diagnosis from other causes of megalocephaly

    Neurology

    (1972)
  • Y Luo et al.

    Spongy degeneration of the CNS in infancy

    Arch Neurol

    (1984)
  • D Leupold et al.

    3-hydroxy-3-methyl-glutaryl-CoA lyase deficiency in an infant with macrocephaly and mild metabolic acidosis

    Eur J Pediatr

    (1982)
  • V Pietrini et al.

    Megalencephaly with formation of Rosenthal fibers in symmetric subependymal gliomatous proliferations: Clinicopathologic report

    Clin Neuropathol

    (1983)
  • D Borrett et al.

    Alexander's disease: A disease of astrocytes

    Brain

    (1985)
  • O Matsubara et al.

    Hemimegalencephaly with hemihypertrophy (Klippel-Trenaunay-Weber syndrome)

    Virchows Arch [A]

    (1983)
  • HR Wiedemann et al.

    The proteus syndrome: Partial gigantism of the hands and/or feet, nevi, hemihypertrophy, subcutaneous tumors, macrocephaly or other skull anomalies and possible accelerated growth and visceral affections

    Eur J Pediatr

    (1983)
  • H Schreier et al.

    Familial megalencephaly or hydrocephalus

    Neurology

    (1974)
  • RE Day et al.

    Normal children with large heads: Benign familial megalencephaly

    Arch Dis Child

    (1979)
  • BA Lewis et al.

    Language and motor findings in benign megalencephaly

    Ann Neurol

    (1983)
  • A Hori et al.

    CNS dysplasia in dysencephalia splanchnocystica (Gruber's syndrome)

    Acta Neuropathol (Berl)

    (1980)
  • MT Jennings et al.

    Endocardial fibroelastosis, neurologic dysfunction and unusual facial appearance in two brothers, coincidentally associated with dominantly inherited macrocephaly

    Am J Med Genet

    (1980)
  • IM Winship

    Sotos syndrome—autosomal dominant inheritance substantiated

    Clin Genet

    (1985)
  • K Wechselberg et al.

    Zur Ubergrosse des hirn- und gesichtsschaedels bei adiposogiganten

    Z Kinderheilk

    (1965)
  • N Amir et al.

    Weaver-Smith syndrome

    Am J Dis Child

    (1984)
  • K Holden et al.

    Diffuse neonatal hemangiomatosis

    Pediatrics

    (1970)
  • EC Burke et al.

    Disseminated hemangiomatosis: The newborn with central nervous system involvement

    Am J Dis Child

    (1964)
  • JH Miles et al.

    Macrocephaly with hamartomas: Bannayan-Zonana syndrome

    Am J Med Genet

    (1984)
  • Cited by (0)

    View full text