Skip to main content

Advertisement

Log in

Migraine and Epilepsy in the Pediatric Population

  • Childhood and Adolescent Headache (S Evers, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology. What complicates matters is that there can be marked similarities between migraine and epilepsy as well as a variety of underlying conditions that predispose children to both seizures and headache. Thus, separating epilepsy from migraine may not be easy, but can be done with a detailed history as well as timely use of ancillary testing. Once children have been diagnosed with epilepsy, migraine, or both, treatment options become essential in attempts to manage these common, yet often disabling, neurological conditions. Acute interventions tend to be condition specific while preventative options may overlap for migraine and epilepsy. In the following review, we will discuss the epidemiology of childhood epilepsy and headache, the association between them, as well as how to differentiate epilepsy from migraine. Treatment strategies will follow before concluding with a discussion on prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of outstanding importance

  1. Haut SR, Bigal ME, Lipton RB. Chronic disorders with episodic manifestations: Focus on epilepsy and migraine. Lancet Neurol. 2006;5:148–57.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Kelley SA, Hartman AL, Kossoff EH. Comorbidity of migraine in children presenting with epilepsy to a tertiary care center. Neurology. 2012;79:468–73. Recent prospective clinical study that correlates with other recent reports that there is a greater comorbidity between epilepsy and headache/migraine than previously indicated.

    Article  PubMed  Google Scholar 

  3. Winawer MR, Connors R, EPGP Investigators. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia. 2013;54(2):288–95. Recent cross section multicenter study of a known cohort of epilepsy patients that demonstrated higher prevalence of migraine than historical reports. Results similar to other recent reports with higher than previously noted rates of migraine in pediatric epilepsy patients. Suggesting a greater association between migraine and epilepsy than previously thought.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Abu-Arafeh I, Razak S, Sivaraman B, Graham C. Prevalence of headache and migraine in children and adolescents: a systematic review of population-based studies. Dev Med Child Neurol. 2010;52:1088–97.

    Article  PubMed  Google Scholar 

  5. Hershey AD. Perimenstrual headache in adolescence. Curr Pain Headache Rep. 2012;16(5):474–6.

    Article  PubMed  Google Scholar 

  6. Sillanpää M, Saarinen M, Schmidt D. Long-term risks following first remission in childhood-onset epilepsy. A population-based study. Epilepsy Behav. 2012;25(2):145–9.

    Article  PubMed  Google Scholar 

  7. Institute of Medicine. Epilepsy across the spectrum: promoting health and understanding. Washington, DC: The National Academy Press; 2012. Available at http://www.iom.edu/epilepsy. *Recent report that indicates epilepsy more prevalent than previously thought.

  8. Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester. Minn Epilepsia. 1991;32:429–45.

    Article  CAS  Google Scholar 

  9. Shorvon SD, Goodridge DM Longitudinal cohort studies of the prognosis of epilepsy: contribution of the National General Practice Study of Epilepsy and other studies. Brain. 2013 Sep 24.

  10. Theodore WH, Spencer SS, Wiebe S, et al. Epilepsy in North America: a report prepared under the auspices of the global campaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health Organization. Epilepsia. 2006;47:1700–22.

    Article  PubMed  Google Scholar 

  11. Deubner DC. An epidemiologic study of migraine and headache in 10–20 year olds. Headache. 1977;17:173–80.

    Article  CAS  PubMed  Google Scholar 

  12. Sillanpaa M. Changes in the prevalence of migraine and other headache during the first seven school years. Headache. 1983;23:15–9.

    Article  CAS  PubMed  Google Scholar 

  13. Liner MS, Stewart WF, Celentano DD, Ziegler D, Sprecher M. An epidemiologic study of headache among adolescents and young adults. JAMA. 1989;261:2211–6.

    Article  Google Scholar 

  14. Stewart WF, Linet MS, Celentano DD, Van Natta M, Siegler D. Age and sex-specific incidence rates of migraine with and without visual aura. Am J Epidemiol. 1991;34:1111–20.

    Google Scholar 

  15. Sillanpaa M. Prevalence of headache in prepuberty. Headache. 1983;23:10–4.

    Article  CAS  PubMed  Google Scholar 

  16. Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. BMJ. 1994;309(6957):765–9.

    Article  CAS  PubMed  Google Scholar 

  17. Dalsgaard-Nielsen T. Some aspects of the epidemiology of migraine in Denmark. Headache. 1970;10:14–23.

    Article  CAS  PubMed  Google Scholar 

  18. Lipton RB, Silberstein SD, Stewart WF. An update on the epidemiology of migraine. Headache. 1994;34:319–28.

    Article  CAS  PubMed  Google Scholar 

  19. Mortimer MJ, Kay J, Jaron A. Epidemiology of headache and childhood migraine in an urban general practice using ad hoc, Vahlquist and IHS criteria. Dev Med Child Neurol. 1992;34:1095–101.

    Article  CAS  PubMed  Google Scholar 

  20. Valquist B. Migraine in children. Int Arch Allergy. 1955;7:348–55.

    Article  Google Scholar 

  21. Small P, Waters WE. Headache and migraine in a comprehensive school. In: Waters, editor. The epidemiology of migraine. Bracknell-Berkshire, England: Boehringer Ingel-helm, Ltd; 1974. p. 56–67.

    Google Scholar 

  22. Sillanpaa M. Prevalence of migraine and other headache in Finnish children starting school. Headache. 1976;15:288–90.

    Article  CAS  PubMed  Google Scholar 

  23. Lewis DW, Ashwal S, Dahl G, Dorbad D, Hirtz D, Prensky A, et al. Practice parameter: evaluation of children and adolescents with recurrent headaches: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2002;59(4):490–8.

    Article  CAS  PubMed  Google Scholar 

  24. Dalsgaard-Nielsen T. Some aspects of the epidemiology of migraine in Denmark. Headache. 1970;10:14–23.

    Article  CAS  PubMed  Google Scholar 

  25. Diamond S, Bigal ME, Silberstein S, Loder E, Reed M, Lipton RB. Patterns of diagnosis and acute and preventive treatment for migraine in the United States: results from the American Migraine Prevalence and Prevention study. Headache. 2007;47:355–63.

    PubMed  Google Scholar 

  26. Stewart WF, Wood C, Reed ML, Roy J, Lipton RB. Cumulative lifetime migraine incidence in women and men. Cephalalgia. 2008;28:1170–8.

    Article  CAS  PubMed  Google Scholar 

  27. Powers SW, Patton SR, Hommel KA, Hershey AD. Quality of life in childhood migraines: clinical impact and comparison to other chronic illnesses. Pediatrics. 2003;112(1 Pt 1):e1–5.

    Article  PubMed  Google Scholar 

  28. Hawkins K, Wang S, Rupnow M. Direct cost burden among insured US employees with migraine. Headache. 2008;48:553–63.

    Article  PubMed  Google Scholar 

  29. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde BW, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–85.

    Article  PubMed  Google Scholar 

  30. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.

    Article  Google Scholar 

  31. Andermann E, Andermann F. Migraine-epilepsy relationships: Epidemiological and genetic aspects. In: Andermann FA, Lugaresi E, editors. Migraine and Epilepsy. Boston: Butterworths; 1987.

    Google Scholar 

  32. Toldo I, Perissinotto E, Menegazzo F, et al. Comorbidity between headache and epilepsy in a pediatric headache center. J Headache Pain. 2010;11:235–40.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Bigal ME, Lipton RB, Cohen J, et al. Epilepsy and migraine. Epilepsy Behav. 2003;4 suppl 2:S13–24.

    Article  PubMed  Google Scholar 

  34. Ottman R, Lipton RB. Comorbidity of migraine and epilepsy. Neurology. 1994;44:2105–10.

    Article  CAS  PubMed  Google Scholar 

  35. Stevenson SB. Epilepsy and migraine headache: Is there a connection? J Pediatr Health Care. 2005;20:167–71.

    Article  Google Scholar 

  36. Kanemura H, Sano F, Ishii S, Ohyama T, Sugita K, Aihara M. Characteristics of headache in children with epilepsy. Seizure. 2013;22(8):647–50. Recent prospective clinical study that correlates with other recent reports that there is a greater comorbidity between epilepsy and headache/migraine than previously indicated.

    Article  PubMed  Google Scholar 

  37. Deprez L, Peeters K, Van Paesschen W, Claeys KG, Claes LR, Suls A, et al. Familial occipitotemporal lobe epilepsy and migraine with visual aura: linkage to chromosome 9q. Neurology. 2007;68:1995–2002.

    Article  CAS  PubMed  Google Scholar 

  38. Polvi A, Siren A, Kallela M, Rantala H, Artto V, Sobel EM, et al. Shared loci for migraine and epilepsy on chromosomes 14q12–q23 and 12q24.2–q24.3. Neurology. 2012;78:202–9.

    Article  CAS  PubMed  Google Scholar 

  39. Imbrici P, Jaffe SL, Eunson LH, Davies NP, Herd C, Robertson R, et al. Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia. Brain. 2004;127:2682–92.

    Article  PubMed  Google Scholar 

  40. Dichgans M, Freilinger T, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet. 2005;366:371–7.

    Article  CAS  PubMed  Google Scholar 

  41. Deprez L, Weckhuysen S, Peeters K, Deconinck T, Claeys KG, Claes LR, et al. Epilepsy as part of the phenotype associated with ATP1A2 mutations. Epilepsia. 2008;49:500–8.

    Article  CAS  PubMed  Google Scholar 

  42. Lebas A, Guyant-Maréchal L, Hannequin D, Riant F, Tournier-Lasserve E, Parain D. Severe attacks of familial hemiplegic migraine, childhood epilepsy and ATP1A2 mutation. Cephalalgia. 2008;28(7):774–7.

    Article  CAS  PubMed  Google Scholar 

  43. Escayg A, MacDonald BT, Meisler MH, Baulac S, Huberfeld G, An- Gourfinkel I, et al. Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2. Nat Genet. 2000;24:343–5.

    Article  CAS  PubMed  Google Scholar 

  44. Claes L, Del-Favero J, Ceulemans B, Lagae L, Van Broeckhoven C, De Jonghe P. De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy. Am J Hum Genet. 2001;68:1327–32.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  45. Frosk P, Mhanni AA, Rafay MF. SCN1A mutation associated with intractable myoclonic epilepsy and migraine headache. J Child Neurol. 2013;28(3):389–91.

    Article  PubMed  Google Scholar 

  46. Riant F, Ducros A, Ploton C, Banbance C, Depienne C, Tournie-Lasserve E. De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. Neurology. 2010;75:967–72.

    Article  CAS  PubMed  Google Scholar 

  47. De Fusco M, Marconi R, Silvestri L, et al. Haplo insufficiency of ATP1A2 encoding the Na+/K+ pump a2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003;33:192–6.

    Article  PubMed  Google Scholar 

  48. Vanmolkot KR, Kors EE, Hottenga JJ, Terwindt GM, Haan JJ, Hoefnagels WA. Novel mutations in the Na+/K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Ann Neurol. 2003;54:360–6.

    Article  CAS  PubMed  Google Scholar 

  49. Gambardella A, Marini C. Clinical spectrum of SCN1A mutations. Epilepsia. 2009;50:20–3.

    Article  CAS  PubMed  Google Scholar 

  50. Wirrell EC, Hamiwka LD. Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls? Epilepsia. 2006;47:1674–81.

    Article  PubMed  Google Scholar 

  51. Clarke T, Baskurt Z, Strug L, Pal D. Evidence of shared genetic risk factors for migraine and rolandic epilepsy. Epilepsia. 2009;50:2428–33.

    Article  PubMed  Google Scholar 

  52. Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain. 2008;131:2264–86.

    Article  PubMed  Google Scholar 

  53. Covanis A. Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis. Pediatrics. 2006;118(4):e1237–43.

    Article  PubMed  Google Scholar 

  54. Gastaut H. A new type of epilepsy: Benign partial epilepsy of childhood with occipital spike-waves. Clin Electroencephalogr. 1982;13:13–22.

    CAS  PubMed  Google Scholar 

  55. Panayiotopoulos CP. Elementary visual hallucinations, blindness, and headache in idiopathic occipital epilepsy: Differentiation from migraine. J Neurol Neurosurg Psychiatry. 1999;57:1371–4.

    Article  Google Scholar 

  56. Giroud M, Couillaut G, Arnould S, et al. Epilepsy with rolandic paroxysms and migraine: A nonfortuitous association. Results of a controlled study. Pediatrie. 1989;44:659–64.

    CAS  PubMed  Google Scholar 

  57. Neut D, Fily A, Cuvellier JC, Vallée L. The prevalence of triggers in pediatric migraine: a questionnaire study in 102 children and adolescents. J Headache Pain. 2012;13(1):61–5.

    Article  PubMed Central  PubMed  Google Scholar 

  58. Balamurugan E, Aggarwal M, Lamba A, Dang N, Tripathi M. Perceived trigger factors of seizures in persons with epilepsy. Seizure. 2013;22(9):743–7.

    Article  CAS  PubMed  Google Scholar 

  59. Parisi P, Piccioli M, Villa MP, et al. Hypothesis on neurophysiopathological mechanisms linking epilepsy and headache. Med Hypotheses. 2008;70:1150–4.

    Article  PubMed  Google Scholar 

  60. Verrotti A, Coppola G, Spalice A, Di Fonzo A, Bruschi R, Tozzi E, et al. Peri-ictal and inter-ictal headache in children and adolescents with idiopathic epilepsy: a multicenter cross-sectional study. Childs Nerv Syst. 2011;27(9):1419–23.

    Article  PubMed  Google Scholar 

  61. Lope RJ, Wong SW, Wu LL. Episodic vomiting and headache in children: consider occipital epilepsy. J Paediatr Child Health. 2010;46(4):204–6.

    Article  PubMed  Google Scholar 

  62. Papatheophilou R, Jeavons PM, Disney ME. Recurrent abdominal pain: a clinical and electroencephalographic study. Dev Med Child Neurol. 1972;14(1):31–44.

    Article  CAS  PubMed  Google Scholar 

  63. Olmez A, Köse G, Turanli G. Cyclic vomiting with generalized epileptiform discharges responsive to topiramate therapy. Pediatr Neurol. 2006;35(5):348–51.

    Article  PubMed  Google Scholar 

  64. Chopra SS, Kulkarni SD, Hegde AU, Shah KN. Cyclical vomiting syndrome with bilateral epileptiform discharges. Indian Pediatr. 2011;48(2):143–5.

    PubMed  Google Scholar 

  65. Murphy JV, Dehkharghani F. Diagnosis of childhood seizure disorders. Epilepsia. 1994;35 Suppl 2:S7–17.

    Article  PubMed  Google Scholar 

  66. Vassella F. [Differential diagnosis of cerebral seizures]. Monatsschr Kinderheilkd. 1992;140(7):391–5.

    CAS  PubMed  Google Scholar 

  67. Sances G, Guaschino E, Perucca P, et al. Migralepsy: A call for revision of the definition. Epilepsia. 2009;50:2487–96.

    Article  PubMed  Google Scholar 

  68. Kossoff EH, Hatfield LA, Ball KL, et al. Comorbidity of epilepsy and headache in patients with Sturge-Weber syndrome. J Child Neurol. 2005;20:678–82.

    Article  PubMed  Google Scholar 

  69. Goh S, Butler W, Thiele EA. Subependymal giant cell tumors in tuberous sclerosis complex. Neurology. 2004;63:1457–61.

    Article  PubMed  Google Scholar 

  70. Klopstock T, May A, Seibel P, et al. Mitochondrial DNA in migraine with aura. Neurology. 1996;46:1735–8.

    Article  CAS  PubMed  Google Scholar 

  71. Gronseth GS, Greenberg MK. The utility of the electroencephalogram in the evaluation of patients presenting with headache: A review of the literature. Neurology. 1995;45:1263–7.

    Article  CAS  PubMed  Google Scholar 

  72. Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S, et al. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology. 2004;63(12):2215–24.

    Article  CAS  PubMed  Google Scholar 

  73. Hershey AD, Kabbouche MA, Powers SW. Treatment of pediatric and adolescent migraine. Pediatr Ann. 2010;39(7):416–23.

    Article  PubMed  Google Scholar 

  74. O'Brien HL, Kabbouche MA, Hershey AD. Treatment of acute migraine in the pediatric population. Curr Treat Options Neurol. 2010;12(3):178–85.

    Article  PubMed  Google Scholar 

  75. Kabbouche MA, Vockell AL, LeCates SL, Powers SW, Hershey AD. Tolerability and effectiveness of prochlorperazine for intractable migraine in children. Pediatrics. 2001;107(4):E62.

    Article  CAS  PubMed  Google Scholar 

  76. Coppola M, Yealy DM, Leibold RA. Randomized, placebo-controlled evaluation of prochlorperazine versus metoclopramide for emergency department treatment of migraine headache. Ann Emerg Med. 1995;26(5):541–6.

    Article  CAS  PubMed  Google Scholar 

  77. Larkin G. Intravenous ketorolac vs intravenous prochlorperazine for the treatment of migraine headaches. Acad Emerg Med. 1999;6(6):668–70.

    Article  CAS  PubMed  Google Scholar 

  78. Brousseau DC, Duffy SJ, Anderson AC, Linakis JG. Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. Ann Emerg Med. 2004;43(2):256–62.

    Article  PubMed  Google Scholar 

  79. Shrestha M, Singh R, Moreden J, Hayes JE. Ketorolac vs chlorpromazine in the treatment of acute migraine without aura. A prospective, randomized, double blind. Arch Intern Med. 1996;156(15):1725–8.

    Article  CAS  PubMed  Google Scholar 

  80. Mathew NT, Kailasam J, Meadors L, Chernyschev O, Gentry P. Intravenous valproate sodium (depacon) aborts migraine rapidly: a preliminary report. Headache. 2000;40(9):720–3.

    Article  CAS  PubMed  Google Scholar 

  81. Tanen DA, Miller S, French T, Riffenburgh RH. Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial. Ann Emerg Med. 2003;41(6):847–53.

    Article  PubMed  Google Scholar 

  82. Shearer P, Riviello J. Generalized convulsive status epilepticus in adults and children: treatment guidelines and protocols. Emerg Med Clin North Am. 2011;29(1):51–64.

    Article  PubMed  Google Scholar 

  83. Yamamoto LG, Yim GK. The role of intravenous valproic acid in status epilepticus. Pediatr Emerg Care. 2000;16:296–8.

    Article  CAS  PubMed  Google Scholar 

  84. Jacob J, Goadsby PJ, Duncan JS. Use of sumatriptan in postictal migraine headache. Neurology. 1996;47:1104.

    Article  CAS  PubMed  Google Scholar 

  85. Linde M, Mulleners WM, Chronicle EP, McCrory DC. Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013;6, CD010608.

    PubMed  Google Scholar 

  86. Cruccu G, Gronseth G, Alksne J, Argoff C, Brainin M, Burchiel K, et al. AAN-EFNS guidelines on trigeminal neuralgia management. Eur J Neurol. 2008;15(10):1013–28.

    Article  CAS  PubMed  Google Scholar 

  87. Freitag FG. Divalproex in the treatment of migraine. Psychopharmacol Bull. 2003;37 suppl 2:98–115.

    PubMed  Google Scholar 

  88. Wheless JW, Clarke DF, Carpenter D. Treatment of pediatric epilepsy: Expert opinion, 2005. J Child Neurol. 2005;20 suppl 1:S1–56.

    PubMed  Google Scholar 

  89. Brandes JL, Saper JR, Diamond M, et al. Topiramate for migraine prevention: A randomized controlled trial. JAMA. 2004;291:965–73.

    Article  CAS  PubMed  Google Scholar 

  90. Mathew NT, Rapoport A, Saper J, et al. Efficacy of gabapentin in migraine prophylaxis. Headache. 2001;41:119–28.

    Article  CAS  PubMed  Google Scholar 

  91. Lampl C, Katsarava Z, Diener HC, et al. Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J Neurol Neurosurg Psychiatry. 2005;76:1730–2.

    Article  CAS  PubMed  Google Scholar 

  92. Miller GS. Efficacy and safety of levetiracetam in pediatric migraine. Headache. 2004;44:238–43.

    Article  PubMed  Google Scholar 

  93. Strahlman RS. Can ketosis help migraine sufferers? A case report. Headache. 2006;46:182.

    Article  PubMed  Google Scholar 

  94. Di Lorenzo C, Sirianni G, Coppola G, et al. Does migraine improve thorough ketogenic diet? Neurol Sci [Abstr]. 2010;31:S225.

    Google Scholar 

  95. Schnabel TG. An experience with a ketogenic dietary in migraine. Ann Intern Med. 1928;2:341–7.

    Article  Google Scholar 

  96. Mauskop A. Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches. Cephalalgia. 2005;25:82–6.

    Article  CAS  PubMed  Google Scholar 

  97. Kossoff EH, Huffman J, Turner Z, et al. Use of the modified Atkins diet for adolescents with chronic daily headache. Cephalalgia. 2010;30:1014–6.

    CAS  PubMed  Google Scholar 

  98. Brna P, Dooley J, Gordon K, et al. The prognosis of childhood headache: A 20-year follow-up. Arch Pediatr Adolesc Med. 2005;159:1157–60.

    Article  PubMed  Google Scholar 

  99. Kienbacher C, Wober C, Zesch H, et al. Clinical features, classification and prognosis of migraine and tension-type headache in children and adolescents: A long-term follow-up study. Cephalalgia. 2006;26:820–30.

    Article  CAS  PubMed  Google Scholar 

  100. Shinnar S, Pellock JM. Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol. 2002;17 Suppl 1:S4–17.

    Article  PubMed  Google Scholar 

Download references

Compliance with Ethics Guidelines

Conflict of Interest

Dr. Christopher B. Oakley served as a consultant for the British Medical Journal and received honoraria from Southwest Florida Pediatric Conference. Dr. Oakley had travel/accommodations expenses covered or reimbursed by Southwest Florida Pediatric Conference and All Children’s Hospital-Tampa/St. Petersburg, Florida.

Dr. Eric H. Kossoff served as a consultant for Atkins Nutritionals, Inc.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christopher B. Oakley.

Additional information

This article is part of the Topical Collection on Childhood and Adolescent Headache

Rights and permissions

Reprints and permissions

About this article

Cite this article

Oakley, C.B., Kossoff, E.H. Migraine and Epilepsy in the Pediatric Population. Curr Pain Headache Rep 18, 402 (2014). https://doi.org/10.1007/s11916-013-0402-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11916-013-0402-3

Keywords

Navigation