Table 2

Antiemetics for the acute/rescue treatment of migraine with and without aura

5. Cyclizine
2–5 yearsOral
Per rectum
0.5–1 mg/kg three times a day, max 3 mg/kg/day, max single dose 25 mgTabs: 50 mg;
Suppository:12.5, 25, 50, 100 mg;
Injection: 50 mg/mL
Drowsiness, dystonia is rare
6–11 years25 mg up to three times a day
12–18 years50 mg up to three times a day
6. Domperidone
2–18 years ≤35 kg
>35 kg
Oral/Per rectum250 µg/kg three times a day,
10 mg three times a day,
Tabs: 10 mg
Suspension: 5 mg/5 mL
Suppository: 30 mg
Avoid in hepatic impairment
Can prolong QT-interval, so caution in heart disease, or with other drugs that can do the same
7. Prochlorperazine
5–11 yearsOral250 µg/kg up to three times a dayTabs: 5 mg; syrup: 5 mg/5 mL
Suppository: 5, 25 mg
Buccal prep: 3 mg tabs placed high between upper lip and gum
Injection: 12.5 mg/mL
Dystonia, akathisia, tardive dyskinesia, all rare
Per rectum5 mg three times a day
Intramuscular6.25 mg, max three times a day
12–18 yearsOral5–10 mg, max three times a day
Per rectum12.5–25 mg three times a day
Buccal1–2 tabs twice daily
Intramuscular12.5 mg up to three times a day
  • Some of the drugs/doses below are those suggested/used by the authors and may be outwith the marketing authorisation. Always check usual reference sources/guidelines when using unfamiliar medicines.11

  • Tabs, tablets.