Antiemetics for the acute/rescue treatment of migraine with and without aura
| 5. Cyclizine | ||||
| 2–5 years | Oral Per rectum Intravenous Subcutaneous | 0.5–1 mg/kg three times a day, max 3 mg/kg/day, max single dose 25 mg | Tabs: 50 mg; Suppository:12.5, 25, 50, 100 mg; Injection: 50 mg/mL | Drowsiness, dystonia is rare |
| 6–11 years | 25 mg up to three times a day | |||
| 12–18 years | 50 mg up to three times a day | |||
| 6. Domperidone | ||||
| 2–18 years ≤35 kg >35 kg | Oral/Per rectum | 250 µg/kg three times a day, 10 mg three times a day, | Tabs: 10 mg Suspension: 5 mg/5 mL Suppository: 30 mg | Avoid in hepatic impairment Can prolong QT-interval, so caution in heart disease, or with other drugs that can do the same |
| 7. Prochlorperazine | ||||
| 5–11 years | Oral | 250 µg/kg up to three times a day | Tabs: 5 mg; syrup: 5 mg/5 mL Suppository: 5, 25 mg Buccal prep: 3 mg tabs placed high between upper lip and gum Injection: 12.5 mg/mL | Dystonia, akathisia, tardive dyskinesia, all rare |
| Per rectum | 5 mg three times a day | |||
| Intramuscular | 6.25 mg, max three times a day | |||
| 12–18 years | Oral | 5–10 mg, max three times a day | ||
| Per rectum | 12.5–25 mg three times a day | |||
| Buccal | 1–2 tabs twice daily | |||
| Intramuscular | 12.5 mg up to three times a day | |||
Some of the drugs/doses below are those suggested/used by the authors and may be outwith the marketing authorisation. Always check usual reference sources/guidelines when using unfamiliar medicines.11
Tabs, tablets.