Population | Pretest (background) probability of neuroblastoma (%) | Test result | Post-test probability of neuroblastoma (%) |
---|---|---|---|
Vague suspicion of neuroblastoma, non-specifically unwell child | 2 | Positive | 63 |
Negative | 0 | ||
Secondary care, distinct suspicion of neuroblastoma | 10 | Positive | 99 |
Negative | 1 | ||
Paraspinal or renal mass, strongly suspected neuroblastoma | 60 | Positive | 99.90 |
Negative | 18 | ||
Unilateral Horner's syndrome | 8 | Positive | 99 |
Negative | 1 | ||
Well infants ∼6 months old, screening investigation | 0.05 | Positive | 20 |
Negative | 0.01 | ||
Opsoclonus-myoclonus syndrome | 55 | Positive | 99.90 |
Negative | 15 |
Reproduced from Erdelyi et al.2 Probability of patients in different clinical contexts having neuroblastoma based on positive and negative urine catecholamine and metabolite tests. Assumes average likelihood ratios (LR) for abnormal urine catecholamines of LR+ 85, LR− 0.15 (sensitivity ∼85% and specificity ∼99%).