Value of serology in the early identification of Pseudomonas aeruginosa infections
| Authors | Subjects’ age and number | Comparison sample | Antigens assayed | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
| Douglas et al45 | 0.1–5.6 years 76 patients | BAL | MAg* Exotoxin A | 53 93 | 82 43 | 26 19 | 94 98 |
| Hayes et al46 | 0–6 years† 69 patients | Sputum Oropharyngeal cultures | Cell lysate Exotoxin A Elastase | 52 49 36 | 90 90 81 | 84 84 65 | 65 64 55 |
| Ratjen et al47 | 1–52 years 375 patients | Alkaline protease Exotoxin A Elastase | 85.4 72.0 76.2 | 97.5 97.5 97.5 | 96.6 95.9 96.2 | 88.8 80.8 83.2 |
*MAg—Multiple Pseudomonas aeruginosa antigens.
†Patients followed up from diagnosis on newborn screening over 6 years.
BAL, bronchoalveolar lavage; NPV, negative predictive value; PPV, positive predictive value.