Recommended eradication therapies for Helicobacter pylori in children
| Options | Medications | Dosages |
|---|---|---|
| Adapted from Gold et al.44 | ||
| First line | ||
| 1 | Amoxicillin | 50 mg/kg/day, up to 1 g day |
| Clarithromycin | 15 mg/kg/day | |
| up to 500 mg twice daily | ||
| Proton pump inhibitor (omeprazole) | 1 mg/kg/day up to 20 mg twice daily | |
| 2 | Amoxicillin | 50 mg/kg/day, up to 1 g day |
| Metronidazole | 20 mg/kg twice daily | |
| up to 500 mg twice daily | ||
| Proton pump inhibitor | 1 mg/kg/day | |
| up to 20 mg twice daily | ||
| 3 | Clarithromycin | 15 mg/kg/day |
| up to 500 mg twice daily | ||
| Metronidazole | 20 mg/kg daily | |
| up to 500 mg twice daily | ||
| Proton pump inhibitor (omeprazole) | 1 mg/kg/day | |
| up to 20 mg twice daily | ||
| Second line | ||
| 4 | Bismuth subsalicylate | 1 tablet (262 mg) four times daily or |
| 15 ml (17.6 mg four times daily) | ||
| Metronidazole | 20 mg/kg twice daily | |
| up to 500 mg twice daily | ||
| Proton pump inhibitor (omeprazole) | 1 mg/kg/day | |
| up to 20 mg twice daily | ||
| Plus an additional antibiotic: | ||
| amoxicillin | 50 mg/kg/day up to 1 g twice daily | |
| or tetracycline | 15 mg/kg/day | |
| or clarithromycin | up to 500 mg twice daily | |
| 5 | Ranitidine bismuth-citrate | 1 tablet four times daily |
| Clarithromycin | 15 mg/kg/day | |
| up to 500 mg twice daily | ||
| Metronidazole | 20 mg/kg/day–500 mg twice daily | |