TY - JOUR T1 - A 6-month-old boy with bilateral breast enlargement JF - Archives of disease in childhood - Education & practice edition JO - Arch Dis Child Educ Pract Ed DO - 10.1136/archdischild-2015-309415 SP - edpract-2015-309415 AU - Gülay Karagüzel AU - Sibel Kul AU - Mustafa İmamoğlu AU - Ayşenur Ökten AU - Güngör Karagüzel Y1 - 2016/02/02 UR - http://ep.bmj.com/content/early/2016/02/02/archdischild-2015-309415.abstract N2 - A 6-month-old boy was referred to our clinic with a 4-month history of progressive bilateral breast enlargement (figure 1). There was no history of maternal medication, infection, trauma, nipple discharge, contact with oestrogen products or familial breast disorder. He had bilateral painless breast enlargement without nipple discharge and signs of inflammation. His testes were both palpable in the scrotum, measuring 2 mL in volume.Figure 1 General appearance of the patient.There were no signs of other endocrine abnormalities. From the patient's clinical presentation, what is the most likely diagnosis? Prepubertal gynaecomastia46,XX disorder of sex development17α-hydroxylase deficiency46,XY disorder of sex developmentBreast abscessOther than breast ultrasound, which investigation(s) would you perform (multiple answers are possible)? Whole blood count and erythrocyte sedimentation rateProlactin, total testosterone and oestradiolFree thyroxine, thyroid stimulating hormone (TSH) and cortisolHuman chorionic gonadotropic hormoneKaryotype … ER -