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Concomitant administration of methotrexate does not improve efficacy of intra-articular joint injections in patients with oligoarticular juvenile idiopathic arthritis
  1. William J Coles,
  2. Eslam Al-Abadi
  1. Childhood Arthritis and Rheumatic Diseases Unit, Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK
  1. Correspondence to Dr William J Coles, Childhood Arthritis and Rheumatic Diseases Unit, Birmingham Children’s Hospital NHS Foundation Trust, Steelhouse Ln, Birmingham B4 6NH, UK; williamcoles{at}nhs.net

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Study question

Setting: Ten hospitals in Italy.

Patients: Patients under the age of 18 with a diagnosis of oligoarticular juvenile idiopathic arthritis were eligible to receive intra-articular steroids in at least two joints or who had received a single joint injection in shoulder, elbow, wrist ankle or knee which had flared within 12 months of a joint injection were eligible for randomisation.

Patients were excluded if they had received methotrexate, biologic disease-modifying drugs, intra-articular or systemic steroids within 3 months prior to enrolment. Non-Steroidal Antinflammatory Drugs NSAIDs were discontinued prior to enrolment. Patients with single knee arthritis were also excluded as this has the highest rate of 12-month remission.

Intervention: 207 patients were randomised …

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