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Fifteen-minute consultation: monogenic forms of diabetes with onset after age 6 months
  1. Emma M Dyer1,
  2. Rakesh Amin2
  1. 1Department of Paediatrics, Lewisham University Hospital, London, UK
  2. 2Department of Endocrinology and Diabetes, Great Ormond Street Hospital London, London, UK
  1. Correspondence to Dr Emma M Dyer, Department of Paediatrics, Lewisham University Hospital, Lewsey Road, London SE13 6LH, UK; emma.m.dyer{at}gmail.com

Abstract

Monogenic forms of diabetes (historically known as Maturity Onset Diabetes of the Young (MODY)) are caused by single gene mutations inherited in an autosomal dominant fashion that result in reduced pancreatic beta cell function. Children with these forms of diabetes may be misdiagnosed as having type 1 or 2 diabetes, which has important implications for treatment, genetic counselling, screening of family members and prognosis. Useful tools now exist to aid in their diagnosis and management. Here, we attempt to outline the clinical features that will help the physician make the differentiation from other diabetes subtypes.

  • Diabetes
  • Monogenic Diabetes
  • Diagnosis
  • Endocrinology
  • Genetics
  • MODY

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Footnotes

  • Contributors ED was responsible for all aspects of this work including the concept of the article and content of the manuscript. RA critically appraised the manuscript and contributed further ideas. Both authors edited the manuscript and agree to be accountable for all aspects of the work.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

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