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Use of high or low FiO2 during initial resuscitation did not impact survival or neurodevelopmental outcomes of preterm infants
  1. Amanda Jane Friend1,2,
  2. Sam J Oddie3
  1. 1 Department of Paediatrics, Leeds General Infirmary, Leeds, UK
  2. 2 University of Leeds School of Medicine, Leeds, UK
  3. 3 Bradford Neonatology, Bradford Royal Infirmary, West Yorkshire, UK
  1. Correspondence to Dr Amanda Jane Friend, Paediatrics, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK; amanda.friend{at}nhs.net

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Study design

Design: Randomised controlled trial.

Allocation: Randomised using computer-generated list.

Blinding: Double-blind.

Study question

Setting: Three hospitals in Spain and the Netherlands.

Patients: Infants born before 32 weeks completed gestation.

Intervention: Initial resuscitation with low (0.3) or high (0.6/0.65) FiO2 immediately after delivery.

Outcomes: Prevalence of cerebral palsy and disability severity according to Bayley-III developmental scores at 24 months corrected age.

Follow-up period: Until 24 months corrected age.

Main results

Prevalence of mild, moderate and severe disability according to Bayley-III developmental scores at 24 months corrected age is summarised in Table 1.

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Table 1

Disability outcomes (pertcentages) for …

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