Subcutaneous calcifications and hypothyroidism: Is there a missing link?
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    Pathologic calcification

    There are two types of pathologic calcification. They are metastatic and dystrophic. Dystrophic calcification is deposition of calcium phosphate in necrotic tissue. Calcium deposition is unrelated to serum calcium and phosphate levels, which are normal . Examples include periventricular calcification in congenital cytomegalovirus infection, calcified atherosclerotic plaques, etc. Metastatic calcification is deposition of calcium phosphate in the interstitium of normal tissues. This is due to increased serum levels of calcium and/or phosphate. Examples include primary hyperparathyrodisim (due to hypercalcemia) and chronic renal failure and primary hypoparathyroidism (due to hyperphosphatemia).
    In this epilogue, the subcutaneous calcifications are due to metastatic calcification rather than dystrophic calcification as there is no necrosis but serum calcium and phosphate levels are deranged.

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