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Narrow-spectrum antibiotics are as effective as broad-spectrum antibiotics in the treatment of community-acquired pneumonia
  1. Anna Selby1,
  2. Katrina Pettit2,
  3. Nick Brown2
  1. 1Department of Child Health, Southampton General Hospital, Southampton, UK
  2. 2Salisbury District Hospital, Salisbury, UK
  1. Correspondence to Dr Anna Selby, Department of Child Health, Level F, South Academic Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK; annaselby{at}doctors.org.uk

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Rationale: Narrow-spectrum antimicrobial therapy is recommended for children with community-acquired pneumonia (CAP) in the 2011 Paediatric Infectious Diseases Society/Infectious Diseases Society of America CAP guideline. However, few studies have compared the effectiveness of narrow-spectrum and broad-spectrum antibiotics in children hospitalised with pneumonia.

Setting: Forty-three tertiary children's hospitals in the USA using data from the Pediatric Health Information System.

Patients: In total, 15 564 children aged 6 months to 18 years, hospitalised with CAP over a 6-year period fulfilled the inclusion criteria. Children with potentially severe pneumonia, those with complex chronic conditions, interhospital transfers and children hospitalised within the previous 30 days or for <2 days were excluded. Children with any of the following …

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