You are here

Article Text

Article menu
Download PDFPDF
Picket
Thalidomide improves clinical remission in children with Crohn's disease
  1. Sophie Harbour1,
  2. Nick Brown2
  1. 1Neonatal Department, Princess Anne Hospital, Southampton, UK
  2. 2Paediatric Department, Salisbury District Hospital, Salisbury, UK
  1. Correspondence to Dr Sophie Harbour, Neonatal Department, Princess Anne Hospital, Southampton SO16 5YA, UK; sophieharbour{at}gmail.com

https://doi.org/10.1136/archdischild-2014-307581

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Methods

    Study design: Double-blinded, placebo controlled, randomised control trial.

    Setting: Six paediatric tertiary care centres in Italy between August 2008 and September 2012.

    Patients: 56 children with Crohn's disease which was active despite immunosuppressive treatment.

    Intervention: Thalidomide (1.5–2.5 mg/kg/day) or placebo once daily for 8 weeks. Open-label extension meant children who received the placebo and did not respond were given thalidomide for 8 weeks. All responders were given an additional course of at least 52 weeks.

    Primary outcome: Clinical remission at 8 weeks, measured using the Paediatric Crohn's Disease Activity Index and PCDAI score at 4 weeks and 8 weeks.

    Follow-up period: Four weeks and 8 weeks.

    Main results: More children (13/28 (46.4%)) who received thalidomide achieved clinical remission than those who received the placebo (3/26 (11.5%)), (RR 4.0 (95% CI 1.2 to 12.5, …

    View Full Text