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Fitting and flailing: recognition of paediatric antiphospholipid syndrome
  1. H Freeman1,
  2. J Patel2,
  3. D Fernandez3,
  4. P Sharples2,
  5. A V Ramanan4
  1. 1Department of Paediatrics, Raigmore Hospital, Inverness, UK
  2. 2Department of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK
  3. 3Department of Paediatric Neurology, Frenchay Hospital, Bristol, UK
  4. 4Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK
  1. Correspondence to Dr A V Ramanan, Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol BS2 8BJ, UK; avramanan{at}hotmail.com

Abstract

Antiphospholipid syndrome (APS) is a systemic autoimmune condition where the presence of antiphospholipid antibodies is thought to predispose to thrombotic events. It is uncommon in the paediatric population, but current diagnostic criteria are based on adult population studies, making assessment of its true paediatric prevalence difficult. We present two cases of paediatric APS, who presented with primary neurological events, and discuss approaches to diagnosis, interpretation of screening investigations, including antinuclear antibodies (ANA), anti-extractable nuclear antigen (ENA) antibodies and lupus anticoagulant. Possible approaches to the management of paediatric APS are discussed.

  • Neurology
  • Rheumatology

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