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Propranolol reduced volume, colour and elevation of infantile haemangiomas

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Study design

Design

Randomised controlled trial.

Allocation

Randomised by clinical pharmacist using minimisation.

Blinding

Staff members, caregivers and participants were blinded to group status.

Study question

Setting

Tertiary hospital in Australia.

Patients

Forty children between 9 weeks and 5 years of age, with infantile haemangiomas (IHs) that could impair function or were in sites with the potential for disfigurement, were too late for corticosteroid therapy (authors do not state a specific age), or had failed corticosteroid therapy.

Intervention

Infants were randomised to oral propranolol 2 mg/kg/day or placebo.

Outcomes

Blinded evaluation of change in IHs volume, colour and elevation.

Follow-up period

Outcomes were assessed at 0, 4, 8, 12, 16, 20 and 24 weeks.

Patient follow-up

An intention to treat analysis was performed. At 2 …

Correspondence to Nick Brown, Salisbury District Hospital, Wilts, UK; n_janbrown{at}yahoo.co.uk

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