Measurement of serum ammonia: its use in clinical practice, pitfalls and limitations
- Metabolic Medicine Unit, Great Ormond Street Hospital for Children with UCL Institute of Child Health, London, UK
- Correspondence to Dr Alexander Broomfield, Metabolic Medicine Unit, Great Ormond Street Hospital for Children with UCL Institute of Child Health, 34 Great Ormond Street, London WC1N 3JH, UK;
- Received 14 April 2011
- Accepted 24 October 2011
- Published Online First 18 November 2011
Hyperammonaemia is a potentially extremely important indicator of impairment in intermediate metabolism. However, lack of experience in sample handling and confusion about what level is significant, can lead to its devaluation as a test. The aim of this article is to help the non-metabolic specialist to decide when it is appropriate to investigate for hyperammonaemia, to discuss potential investigatory pitfalls and to help in interpretation of results.
Competing interests None.
Provenance and peer review Commissioned; externally peer reviewed.