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Paracetamol/codeine probably had equivalent analgesia to ibuprofen in children with extremity injuries

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Study design

Design

Randomised double-blinded controlled trial.

Allocation

Concealed (sealed opaque envelopes).

Blinding

Blinded (patient, parent, investigator and treating physician).

Study question

Setting

Large emergency department in the USA.

Patients

68 children and young people, 5–17 years of age (mean age 10.4 years), who presented to the emergency department with a limb injury not requiring immediate treatment and a pain score of at least 5/10. Exclusion criteria included recent use (<6 h) of analgesics, allergy to study medicines, recent use of central nervous system altering substances, non-English language speakers and inability to use the pain scoring tool.

Intervention

34 children were assigned to a single dose of ibuprofen (10 mg/kg, maximum 400 mg), and 34 were assigned to paracetamol−codeine (1 …

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