Arch Dis Child Educ Pract Ed 98:31 doi:10.1136/edpract-2012-302634a
  • Dermatophile

Dermatophile answers

  1. N P Burrows
  1. Department of Dermatology, Addenbrooke's Hospital, Cambridge, UK
  1. Correspondence to Dr Moumita Chattopadhyay, Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; drmchattopadhyay{at}
  • Received 8 July 2012
  • Revised 8 July 2012
  • Accepted 10 August 2012


From questions on page 16.


Answer is C, Linear immunoglobulin A (IgA) dermatosis is an autoimmune subepidermal vesiculobullous disease of children (chronic bullous dermatosis of childhood) and adults. It is the most common acquired blistering disease in the paediatric population and can appear as early as 6 months of age.1 Vesicles and bullae are usually arranged in an annular manner described as the ‘cluster of jewels’ appearance. Lesions in children occur mostly on the lower abdomen and anogenital areas with frequent oral and ocular involvement. Blood tests show antibodies directed against a 97-kd antigen in the lamina lucida of the dermoepidermal junction, and direct immunofluorescence shows linear deposition of IgA at the basement membrane zone. Remission occurs …