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How to use… alkaline phosphatase in neonatology
  1. Robert J Tinnion1,
  2. Nicholas D Embleton2
  1. 1Newcastle Neonatal Service, Newcastle upon Tyne, UK
  2. 2Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK
  1. Correspondence to Nicholas D Embleton, Newcastle University, Institute of Health & Society, Newcastle upon Tyne NE1 4LP, UK; n.d.embleton{at}ncl.ac.uk

Abstract

Alkaline phosphatase (ALP) is regularly measured in clinical practice. Changes in serum levels are observed in a number of clinical conditions. In neonatology, it has been proposed as a useful marker for both a diagnosis and an indication of the severity of metabolic bone disease (MBD) in infants born preterm. Nutritional practices, aimed at reducing the occurrence or severity of MBD, have led to ALP being proposed as a stand-alone means of monitoring treatment. The current evidence does not support this use: ALP only achieves usefulness in a diagnostic and monitoring capacity when combined with other serum and imaging techniques.

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Footnotes

  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

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