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Structured abstracts of sentinel articles: Picket
Propranolol reduced volume, colour and elevation of infantile haemangiomas

https://doi.org/10.1136/edpract-2011-301220

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    Study design

    Design

    Randomised controlled trial.

    Allocation

    Randomised by clinical pharmacist using minimisation.

    Blinding

    Staff members, caregivers and participants were blinded to group status.

    Study question

    Setting

    Tertiary hospital in Australia.

    Patients

    Forty children between 9 weeks and 5 years of age, with infantile haemangiomas (IHs) that could impair function or were in sites with the potential for disfigurement, were too late for corticosteroid therapy (authors do not state a specific age), or had failed corticosteroid therapy.

    Intervention

    Infants were randomised to oral propranolol 2 mg/kg/day or placebo.

    Outcomes

    Blinded evaluation of change in IHs volume, colour and elevation.

    Follow-up period

    Outcomes were assessed at 0, 4, 8, 12, 16, 20 and 24 weeks.

    Patient follow-up

    An intention to treat analysis was performed. At 2 years, …

    Correspondence to Nick Brown, Salisbury District Hospital, Wilts, UK; n_janbrown{at}yahoo.co.uk

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    Footnotes

    • Sources of funding Sydney Children's Hospital Foundation, Pediatric Cardiac Fund, and the Touch by Olivia Foundation.

    Footnotes

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.