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How to use serum ammonia
  1. Alexander Broomfield,
  2. Stephanie Grunewald
  1. Metabolic Medicine Unit, Great Ormond Street Hospital for Children with UCL Institute of Child Health, London, UK
  1. Correspondence to Dr Alexander Broomfield, Metabolic Medicine Unit, Great Ormond Street Hospital for Children with UCL Institute of Child Health, 34 Great Ormond Street, London WC1N 3JH, UK; Brooma{at}gosh.nhs.uk

Abstract

Hyperammonaemia is a potentially extremely important indicator of impairment in intermediate metabolism. However, lack of experience in sample handling and confusion about what level is significant, can lead to its devaluation as a test. The aim of this article is to help the non-metabolic specialist to decide when it is appropriate to investigate for hyperammonaemia, to discuss potential investigatory pitfalls and to help in interpretation of results.

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Footnotes

  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

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