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Lactobacillus GG prevented nosocomial gastrointestinal and respiratory tract infections

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Question

In hospitalised children (patients) does treatment with Lactobacillus rhamnosus GG (LGG) (treatment) prevent the development of nosocomial gastrointestinal or respiratory tract infections (outcome)?

Methods

Design

Randomised placebo-controlled trial.

Allocation

Computer generated random number list. Concealment method not explicitly stated.

Blinding

Double-blind.

Setting

Children's Hospital Zagreb.

Patients

Children older than 12 months admitted to hospital from November 2007 to May 2008. Excluded children with immunodeficiency, cow's milk allergy, cancer, chronic illness or anticipated hospital stay <3 days.

Intervention

376 children allocated to LGG product (109 CFU) in 100 ml of fermented milk product and 366 to fermented milk only (placebo), then monitored clinically each day with laboratory confirmation for nosocomial infections.

Outcomes

The number and severity of nosocomial gastrointestinal and respiratory infections and hospital length of stay.

Follow-up period

Up to 7 days after discharge.

Patient follow-up

360 (96%) children in the LGG group and 354 (97%) children in the …

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