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Paracetamol/codeine probably had equivalent analgesia to ibuprofen in children with extremity injuries

https://doi.org/10.1136/adc.2010.192435

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    Study design

    Design

    Randomised double-blinded controlled trial.

    Allocation

    Concealed (sealed opaque envelopes).

    Blinding

    Blinded (patient, parent, investigator and treating physician).

    Study question

    Setting

    Large emergency department in the USA.

    Patients

    68 children and young people, 5–17 years of age (mean age 10.4 years), who presented to the emergency department with a limb injury not requiring immediate treatment and a pain score of at least 5/10. Exclusion criteria included recent use (<6 h) of analgesics, allergy to study medicines, recent use of central nervous system altering substances, non-English language speakers and inability to use the pain scoring tool.

    Intervention

    34 children were assigned to a single dose of ibuprofen (10 mg/kg, maximum 400 mg), and 34 were assigned to paracetamol–codeine (1 …

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    Footnotes

    • Provenance and peer review Commissioned; internally peer reviewed.