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Q In adults and children with chronic asthma, is omalizumab (a recombinant humanised monoclonal anti-IgE referred to as rhuMAb-E25, rhu-Mab, or Xolair) better than placebo for clinical outcomes?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Respirology ★★★★★★☆ Paediatrics ★★★★★★☆ Allergy & immunology ★★★★★☆☆
Cochrane Airways Group Asthma and Wheeze trials register (up to February 2006), reference lists of relevant studies and review articles, all pharmaceutical companies producing anti-IgE formulations, 2 websites (www.fda.gov and www.clinicalstudyresults.org), meeting abstracts, and experts in the field.
Study selection and assessment:
randomised and blinded controlled trials (RCTs) in any language that included adults and children with chronic asthma and compared anti-IgE at any dose or route with placebo. 14 RCTs (n = 3143) met the selection criteria. Quality …
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