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Environmental and dietary interventions in the first 5 years of life did not reduce risk of asthma and allergic disease

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Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Allergy & immunology ★★★★★★☆ Paediatrics ★★★★★☆☆

METHODS

Embedded ImageDesign:

randomised, 2×2 factorial design, placebo controlled trial.

Embedded ImageAllocation:

{concealed*}.

Embedded ImageBlinding:

blinded {participants [diet intervention only], outcome assessors, and laboratory staff}.*

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

{antenatal clinics of 6 hospitals in Sydney, Australia.}†

Embedded ImageParticipants:

616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma or frequent wheezing in a first degree relative. Exclusion criteria included a cat in the home and a vegetarian diet. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or neonatal disease were withdrawn.

Embedded ImageInterventions:

active HDM intervention (n  =  308), consisting of an allergen impermeable barrier on …

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