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Wet wrap bandages for 4 weeks did not differ from topical ointments but increased skin infections in paediatric atopic eczema

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In children with moderate to severe atopic eczema, are wet wrap bandages more effective than topical ointments alone for maintenance treatment?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Paediatrics ★★★★☆☆☆

METHODS

Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

unclear concealment.*

Embedded ImageBlinding:

blinded (scoring nurse).*

Embedded ImageFollow up period:

1 month.

Embedded ImageSetting:

a secondary care paediatric department at Fairfield General Hospital, Bury in Greater Manchester, UK.

Embedded ImagePatients:

50 children 3–60 months of age who were diagnosed with moderate to severe atopic eczema according to Hanifin and Rajka criteria, and had a severity rating of moderate or severe according to the SCORing Atopic Dermatitis (SCORAD) index (score ⩾ 15). Children with active skin infection at enrolment, previous allergic reactions to proposed trial treatments, or eczema predominantly on the face were excluded.

Embedded ImageIIntervention:

wet wraps (n  =  28) or usual care (n  =  22) for 4 weeks. Wet wrap bandages were initially applied 24 hours/day over 1% hydrocortisone ointment, and if necessary, topical steroids for 1 week. …

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