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Teratogenicity of anti-epileptic drugs

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Some three or four of every 1000 pregnant women have epilepsy. Anti-epileptic drugs (AEDs) such as sodium valproate, carbamazepine, barbiturates, and phenytoin have been associated with increased risk of congenital malformations but there is little evidence about newer AEDs. The UK Epilepsy and Pregnancy Register was established in 1996 and the findings up to the end of March 2005 have been published (

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