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Setting: Birth cohort of general population of Zealand region, Denmark.
Patients: At the age of 1 week, 700 infants were recruited and observed via daily parental diaries until the age of 3 years. Included in the trial were children who developed recurrent troublesome lung symptoms, defined as: 5 episodes in 6 months of cough, dyspnoea or wheeze severely affecting the well-being of the child; 4 weeks of continuous symptoms; severe episode requiring admission or treatment with oral steroids. Three months of inhaled fluticasone was given at the diagnosis of recurrent troublesome lung symptoms and continued for another 6 months if symptoms recurred.
Intervention: Children older than 1 year of age were assessed by a study physician at each acute episode (≥3 consecutive days of cough, dyspnoea or wheeze severely affecting the well-being of the child) and randomly allocated …
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