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Answers to Dermatophile
  1. Vânia Oliveira Carvalho,
  2. Renata Robl,
  3. Marjorie Uber,
  4. Kerstin Taniguchi Abagge,
  5. Leide Parolin Marinoni,
  6. Juliana Gomes Loyola Presa
  1. Division of Pediatric Dermatology, Department of Pediatrics, Federal University of Paraná, Hospital de Clínicas da UFPR, Curitiba, Paraná, Brazil
  1. Correspondence to Vânia Oliveira Carvalho, Department of Pediatric Dermatology, Hospital de Clinicas – UFPR, Rua Richard Strauss 62—Vista Alegre, Curitiba/Paraná; CEP 80-820-110, Brazil; rcarvalho50{at}hotmail.com

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From the questions on page 185.

Answer to question 1

B—Langerhans cell histiocytosis (LCH): Abnormal clonal proliferation of histiocytes, resembling Langerhans cells, and its accumulation in different tissues and organs. LCH exhibits heterogeneous clinical pictures and evolution—it varies from the isolated cutaneous lesion with spontaneous resolution to severe cases involving the liver, spleen, lung and haematopoietic system.1 The most common skin lesion is similar to seborrhoeic dermatitis, but exhibits petechiae and purpura, and affects the scalp, eyebrows, ears and intertriginous areas.2 Seborrhoeic-like plaques resistant to conventional therapy, no improvement until 8 months of age (both facts described in case number 1), as well as the presence of hepatosplenomegaly should indicate the hypothesis of LCH and, therefore, skin biopsy …

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