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Investigation and management of a child who is immunocompromised and neutropoenic with pulmonary infiltrates
1 University Hospital, Queens Medical Centre, Nottingham, UK
2 Children’s Brain Tumour Research Centre, Institute of Child Health, University of Nottingham, Nottingham, UK
Correspondence to:
Correspondence to Professor H Vyas, University Hospital, Queens Medical Centre, Nottingham, NG72UH; harish.vyas@nuh.nhs.uk
| The first 150 words of the full text of this article appear below. |
Paediatric neutropoenia encompasses a vast range of congenital and acquired causes. Postinfectious neutropoenia represents the most common cause of acquired isolated neutropoenia.1 Neutropoenia following viral infections tend to be brief and usually resolve spontaneously without any serious side effects. These patients therefore do not have the same risk of sepsis and pulmonary complications as those patients with aplastic anaemia, congenital immunodeficiencies or those treated for cancer associated with neutropoenia. In the latter group pancytopoenia may be prolonged resulting in an increased risk of bacterial, viral, fungal and parasitic infections. Bone marrow failure occurs due to the disease process or following myelotoxic chemotherapy, irradiation and post haematopoeitic stem cell transplant (HSCT).
Advances in the treatment and supportive care for childhood cancer have resulted in the expected outcome being one of cure. However, in the intervening period the complications arising from neutropoenia may contribute to a significant morbidity and mortality. Pulmonary infiltrates
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