GUIDELINE REVIEW
Guideline review: management of invasive meningococcal disease, SIGN
Correspondence to:
J H Baumer, Little Luson, Nr Yealmpton, Plymouth PL8 2JD, UK; harry@luson.plus.com
| The first 150 words of the full text of this article appear below. |
Despite advances in prevention and management, invasive meningococcal disease remains an important cause of mortality and morbidity in the UK; it is the most common infectious cause of death in children aged between 1 and 5 years. The overall case fatality rate in England, Wales and Northern Ireland in 2002–2003 was 5.6%, with an annual rate of confirmed meningococcal disease of 52.9 per 100 000 in the under 1 year age group, 18.8 per 100 000 in the 1–4 years age group, and 3.1 per 100 000 in the 5–14 years age group.1 Since 1999, when specific immunisation was introduced, the number of cases due to meningococcus serogroup C has reduced considerably. Over the same time there has been a slight reduction in the number of cases caused by the B serogroup.
A widely used management algorithm was published in 1999 by the St Mary’s Paediatric Intensive Care Unit, based
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