ARCHIVISTS
Genetics of hypertrophic cardiomyopathy of childhood onset
| The first 150 words of the full text of this article appear below. |
It is unusual for hypertrophic cardiomyopathy to become manifest before the age of 14 years. The adult-onset disease is caused by mutations in any of a number of genes that encode sarcomere proteins. These include the genes for cardiac β-myosin heavy chain (MYH7), cardiac myosin-binding protein C (MYBPC3), cardiac troponin T (TNNT2), cardiac troponin 1 (TNNI3), essential myosin light chain (MYL3), regulatory myosin light chain (MYL2), 
tropomyosin (TPM1), cardiac actin (ACTC) and titin (TTN). Gene mutations known to cause ventricular hypertrophy in childhood include those for the 
2 regulatory subunit of ANP-activated protein kinase (PRKAG2) and lysosome-associated membrane protein 2 (LAMP2). The genetic contribution to childhood-onset disease is, however, uncertain. Now researchers in Boston and Houston (Hiroyuki Morita and colleagues. New England Journal of Medicine 2008;358:1899–908)
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in ADC Online
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
