EVIDENCE-BASED MEDICINE
Etomidate had shorter induction and recovery times than midazolam for fracture reduction
In children and adolescents presenting with a displaced extremity fracture who require sedation, does etomidate show faster onset and recovery than midazolam?
Keywords: analgesics (non-narcotic); etomidate; fractures (closed); hypnotics and sedatives; manipulation (orthopaedic); midazolam; pain
| The first 150 words of the full text of this article appear below. |
Di Liddo L, D'Angelo A, Nguyen B, et al. Etomidate versus midazolam for procedural sedation in pediatric outpatients: a randomized controlled trial. Ann Emerg Med 2006;48:433â40.
Clinical impact ratings Emergency medicine âââââââ Paediatrics (general) âââââââ
Design:
randomised controlled trial.
Allocation:
concealed.*
Blinding:
blinded (patients, investigators, {data collectors, outcome assessors, and data analysts}
).*
Follow up period:
up to discharge.
Setting:
emergency department (ED) of a tertiary care paediatric hospital.
Patients:
100 patients 2–18 years of age (mean age 8.7 y, 50% boys) who presented to the ED with a displaced extremity fracture requiring sedation and analgesia for closed reduction. Exclusion criteria included respiratory tract infection, haemodynamic instability, recent head injury, known seizure disorder, heart or lung disease, craniofacial anomaly, adrenocortical dysfunction, pregnancy, allergy to study drugs, consumption of solids <6 hours or liquids <2 hours previously, and inability to obtain intravenous (IV) access.
Intervention:
etomidate, 0.2 mg/kg
Columbia University, New York City, New York, USA
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