EVIDENCE-BASED MEDICINE
Review: LABAs are better than leukotriene receptor antagonists when added to inhaled corticosteroids in recurrent asthma
In patients with recurrent asthma, what is the effectiveness of adding long acting β2 agonists (LABAs) or leukotriene receptor antagonists (LTRAs) to inhaled corticosteroids (ICSs)?
Keywords: adrenal cortex hormones; adrenergic β agonists; asthma; leukotriene antagonists
| The first 150 words of the full text of this article appear below. |
Ducharme FM, Lasserson TJ, Cates CJ. Long-acting beta2-agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma. Cochrane Database Syst Rev 2006;(4):CD003137.
Clinical impact ratings GP/FP/Primary care âââââââ IM/Ambulatory care âââââââ Allergy & immunology âââââââ Paediatrics âââââââ
Data sources:
Medline, CINAHL, EMBASE/Excerpta Medica, Cochrane Central Register of Controlled Trials, Cochrane Airways Group Specialised Register (to March 2006), hand searches of respiratory journals and meeting abstracts, and bibliographies of relevant published and unpublished studies and reviews.
Study selection and assessment:
randomised controlled trials (RCTs) that evaluated the effectiveness of adding LABAs (salmeterol or formoterol) or LTRAs (montelukast, pranlukast, zafirlukast, or zileuton) to ICSs for recurrent asthma. Rescue and asthma medications were permitted at a constant dose. 15 RCTs (age range 6–79 y) met the selection criteria; 1 RCT included children. Quality assessment was based on the 5 point Jadad scale; 8 RCTs had scores of 5.
Outcomes:
number of
Hamden Internal Medicine Associates, New Haven, Connecticut, USA
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
