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Archives of Disease in Childhood - Education and Practice 2007;92:ep160
Copyright © 2007 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

EVIDENCE-BASED MEDICINE

Vaccinating infants with a wide long needle was non-inferior to a narrow short needle for immune response

Diggle L, Deeks JJ, Pollard AJ. Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial. BMJ 2006;333:571.[Abstract/Free Full Text]

Q Is vaccination of infants with a wide long needle non-inferior to a narrow short needle for immune response and local reactions?

Clinical impact ratings Paediatrics ******* Infectious disease ******{star} Public health ******{star}

Keywords: diphtheria tetanus pertussis vaccine; drug eruptions; haemophilus vaccines; needles; vaccination

The first 150 words of the full text of this article appear below.

METHODS


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Design: randomised controlled non-inferiority trial.


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Allocation: concealed.*


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Blinding: blinded (data entry clerks and laboratory staff).*


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Follow up period: 3–4.5 months.


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Setting: 18 general practices in 2 primary care trusts in the UK.


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Participants: 696 healthy infants due to receive their first immunisation (mean age 62 d, mean weight 5300 g, 52% boys). Exclusion criteria were <37 weeks gestation, birth weight <2500 g, or treatments or conditions that could bias evaluation of immune response.


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Intervention: infants were allocated to vaccination with a 23 gauge, 25 mm needle (wide long needle, n = 240); a 25 gauge, 16 mm needle (narrow short needle, n = 230); or a 25 gauge, 25 mm needle (narrow long needle, n = 226). At 2, 3, and 4 months of age, infants received a combined diphtheria, pertussis, tetanus, and Haemophilusinfluenzae type b vaccine administered into the right thigh and a meningococcal C vaccine into the . . . [Full text of this article]

Manjula Datta, MD

The Tamilnadu Dr. MGR Medical University Chennai, India


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