Register for email alerts and news feeds:
This journal | BMJ Group
rss
Archives of Disease in Childhood - Education and Practice 2007;92:ep127
Copyright © 2007 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

EVIDENCE-BASED MEDICINE

Review: omalizumab reduces exacerbation and steroid use in chronic asthma

Walker S, Monteil M, Phelan K, et al. Anti-IgE for chronic asthma in adults and children. Cochrane Database Syst Rev 2006;(2):CD003559.

Q In adults and children with chronic asthma, is omalizumab (a recombinant humanised monoclonal anti-IgE referred to as rhuMAb-E25, rhu-Mab, or Xolair) better than placebo for clinical outcomes?

Clinical impact ratings GP/FP/Primary care ******{star} Respirology ******{star} Paediatrics ******{star} Allergy & immunology *****{star}{star}

Keywords: antibodies (anti-idiotypic); antibodies (monoclonal); asthma

The first 150 words of the full text of this article appear below.

METHODS


Formula

Data sources: Cochrane Airways Group Asthma and Wheeze trials register (up to February 2006), reference lists of relevant studies and review articles, all pharmaceutical companies producing anti-IgE formulations, 2 websites (www.fda.gov and www.clinicalstudyresults.org), meeting abstracts, and experts in the field.


Formula

Study selection and assessment: randomised and blinded controlled trials (RCTs) in any language that included adults and children with chronic asthma and compared anti-IgE at any dose or route with placebo. 14 RCTs (n = 3143) met the selection criteria. Quality assessment of individual RCTs was based on Jadad scores. All of included RCTs had fair to high quality.


Formula

Outcomes: reduction or termination of steroid (inhaled, oral, or both) use from baseline or run-in period, and asthma exacerbation (defined by hospital admissions, emergency room visits, days lost from work or school, unscheduled doctor visits, or increase in medication).

MAIN RESULTS

Omalizumab reduced asthma exacerbations, hospital admission, and some types of . . . [Full text of this article]

P John Rees, MD

King’s College School of Medicine
London, UK


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

This Article

Services
Citing Articles
Google Scholar
PubMed
Bookmark with

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Latest from ADC

 

ADC is co-owned by the RCPCH and is the official journal of the European Academy of Paediatrics

BMJ Careers - Latest Paediatrics and Paediatric Surgery Jobs

Paediatrics and Paediatric Surgery Jobs

Show me all >>