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Archives of Disease in Childhood - Education and Practice 2007;92:ep126
Copyright © 2007 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

EVIDENCE-BASED MEDICINE

Environmental and dietary interventions in the first 5 years of life did not reduce risk of asthma and allergic disease

Marks GB, Mihrshahi S, Kemp AS, et al. Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol 2006;118:53–61.[CrossRef][Medline]

Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?

Clinical impact ratings GP/FP/Primary care ******{star} Allergy & immunology ******{star} Paediatrics *****{star}{star}

Keywords: asthma

The first 150 words of the full text of this article appear below.

METHODS


Formula

Design: randomised, 2x2 factorial design, placebo controlled trial.


Formula

Allocation: {concealed*}{dagger}.


Formula

Blinding: blinded {participants [diet intervention only], outcome assessors, and laboratory staff}{dagger}.*


Formula

Follow up period: 5 years.


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Setting: {antenatal clinics of 6 hospitals in Sydney, Australia.}{dagger}


Formula

Participants: 616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma or frequent wheezing in a first degree relative. Exclusion criteria included a cat in the home and a vegetarian diet. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or neonatal disease were withdrawn.


Formula

Interventions: active HDM intervention (n = 308), consisting of an allergen impermeable barrier on the child’s bed and pillow, regular washing of bedding, and use of a benzyl benzoate containing solution in the wash every 3 months; or control HDM (n = 308), consisting of usual care. Active . . . [Full text of this article]

Thomas M Ball, MD, MPH

University of Arizona, Tucson, Arizona, USA


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