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Archives of Disease in Childhood - Education and Practice 2006;91:ep124
Copyright © 2006 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

EVIDENCE-BASED MEDICINE

Mometasone furoate nasal spray was more effective for symptom relief of acute rhinosinusitis than amoxicillin or placebo

Meltzer EO, Bachert C, Staudinger H. Treating acute rhinosinusitis: comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo. J Allergy Clin Immunol 2005;116:1289–95.[CrossRef][Medline]

In patients with acute, uncomplicated rhinosinusitis lasting >=7 days, what is the relative effectiveness of mometasone furoate nasal spray, amoxicillin, and placebo?

Clinical impact ratings GP/FP/Primary care *****{star}{star} Allergy & immunology *****{star}{star} Respirology *****{star}{star}

Keywords: rhinitis; sinusitis; pregnadienediols; amoxicillin

The first 150 words of the full text of this article appear below.

METHODS


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Design: randomised controlled trial.


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Allocation: unclear allocation concealment.*


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Blinding: blinded (patients and healthcare providers).*


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Follow up period: up to 29 days.


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Setting: 71 medical centres in 14 countries.


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Patients: 981 patients >=12 years of age (mean age 35 y, 66% women) with signs and symptoms of acute rhinosinusitis for >=7 days but <=28 days and major symptom score (MSS) >=5 but <=12, with <=3 of 5 symptoms rated as severe (based on the sum of scores for rhinorrhoea, postnasal drip, nasal congestion/stuffiness, sinus headache, and facial pain/pressure/tenderness).


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Intervention: mometasone furoate nasal spray, 200 µg, once daily for 15 days (n = 243); mometasone spray, 200 µg, twice daily for 15 days (n = 235); amoxicillin, 500 mg, 3 times daily for 10 days (n = 251); or placebo (n = 252).


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Outcomes: main outcome was mean MSS over days 2–15 (treatment phase). Secondary outcomes included mean total symptom score, individual . . . [Full text of this article]

Morten Lindbæk, MD

University of Oslo, Oslo, Norway


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